Methylhydrazine → HCID 178436950, compound

HRID 859749Notes

Reaction equation

HRID 859749 reaction equation
[CH3:1][NH:2][NH2:3].O=[C:5]([CH2:12][CH3:13])[CH2:6][C:7](OCC)=[O:8]>CO>[CH2:12]([C:5]1[CH:6]=[C:7]([OH:8])[N:2]([CH3:1])[N:3]=1)[CH3:13]

Participants

4

Reactant 2

HCID 6061MethylhydrazineHCID 78656Ethyl 3-oxovalerate

Product 1

HCID 178436950HCID 178436950, compoundYield 97.5%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Conditions

Temperature
45 °C

Procedure

Methylhydrazine (31.6 g, 0.687 mol) in methanol (100 mL) was added dropwise to a solution of ethyl 3-oxopentanoate (100 g, 0.694 mol) in methanol (280 mL) over a period of 45 min, during which time the temperature increased to 45° C. The reaction mixture was then allowed to stir at room temperature overnight and then evaporated, affording 84.5 g (97%) of the crude title product.

Workup

  1. customevaporated

Sources & evidence

ORD record
ord-6917c86496284b4b9835dd1279ee3a2b
Source dataset
uspto-grants-2006_12
Patent number
US07151105B2

Reaction notes

Loading…