Hydrochloric Acid → HCID 69618831, compound

Participants

Reaction Conditions

Reaction Steps

Into a three-neck flask, 2,3,4-tri(4-acetyloxy-butyloxy)benzaldehyde (40.0 g), malonic acid (10.6 g), piperidine (1 ml) and 100 mL of pyridine were added and stirred at 110° C. for 5 hours. After cooling, water (500 ml) and potassium hydroxide (26.0 g) were added and stirred at 60° C. for 2 hours. After cooling, concentrated hydrochloric acid was added until the reaction solution became acidic, and the resulting reaction solution was extracted with ethyl acetate and washed with water. The extract was concentrated and then purified by column chromatography to obtain the titled compound (30.1 g). Yield: 90%.

Provenance & Evidence