Water → HCID 10411292, compound

Participants

Reaction Steps

213 mg (0.38 mmol) of 2-(4-tert-butyldimethyl-silyloxy-2-difluoromethylbenzimidazol-1-yl)-4-(2-hydroxymethylpyrrolidin-1-yl)-6-morpholinopyrimidine dissolved in anhydrous THF (7 ml) was added with tetra-n-butylammoniumfluoride (0.4 ml, 1M THF solution) at room temperature and stirred for 30 minutes. The reaction solution was added with water, extracted several times with ethyl acetate, washed with saturated saline solution and dried over anhydrous magnesium sulfate. The solvent was removed under the reduced pressure and the residue was purified by silica gel column chromatography (n-hexane ethyl acetate=1:4) to obtain 101 mg (yield: 60%) of the titled compound as colorless crystals.

Provenance & Evidence