Phosphorus oxychloride → HCID 17954540, compound

Participants

Reaction Steps

Prepared using general procedure 3; 6-Bromo-2-hydroxy-4-(3,4-dichlorophenyl)aminoquinoline (1.94 g, 5.05 mmol) and 30 mL of POCl3 were heated to 120° C. for 4 h. Isolation afforded 1.209 g of material (3.00 mmol, 60%). 1H NMR (300 MHz, DMSO): 9.69(s, 1H), 8.71(s, 1H), 7.91(d, 1H, J=8.88 Hz), 7.78(d, 1H, J=8.88 Hz), 7.69(d, 1H, J=8.88 Hz), 7.68(s, 1H), 7.44(dd, 1H, J=8.68, 2.22 Hz), 6.91(m, 1H).

Provenance & Evidence