Phosphorus oxychloride → HCID 17954548, compound

Participants

Reaction Steps

Prepared using general procedure 3; 6-Fluoro-2-hydroxy-4-(3,4-dichlorophenyl)aminoquinoline (2.136 g, 6.6 mmol) and 30 mL of POCl3 were heated to 120° C. for 4 h. Isolation afforded 0.654 g of material (1.914 mmol, 29%). 1H NMR (300 MHz, DMSO): 9.55(s, 1H), 8.27(dd, 1H, J=10.50, 2.02 Hz), 7.92(dd, 1H, J=8.88, 5.65 Hz), 7.70(m, 3H), 7.45(dd, 1H, J=8.48, 2.02 Hz), 6.90(s, 1H).

Provenance & Evidence