1-(2,3-Xylyl)piperazine → HCID 69605101, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1-(2,3-dimethylphenyl)-piperazine (1.13 g, 5.94 mmol) and [(2R)-8-methyl-2,3-dihydro[1,4]dioxino[2,3-f]quinolin-2-yl]methyl 4-bromobenzene-sulfonate (871 mg, 1.93 mmol) in anhydrous DMSO (10 mL) was heated overnight at 70° C. The reaction was diluted with saturated aqueous sodium bicarbonate (50 mL) and extracted with EtOAc (3×50 mL). The combined organic layers were dried over MgSO4, filtered, and concentrated in vacuo. Flash chromatography on silica gel (50% EtOAc/hexanes) afforded 700 mg (90%) of the title compound as a white solid: mp 112–113° C.; MS (ESI) m/z 404 [M+H]+.

Provenance & Evidence