Sulfuric Acid → 6-Fluoro-2-piperazin-1-yl-quinoline

HRID 860025Notes

Reaction equation

HRID 860025 reaction equation
[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([N:12]1[CH2:17][CH2:16][N:15](C=O)[CH2:14][CH2:13]1)[CH:6]=[CH:5]2.S(=O)(=O)(O)O>>[F:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([N:12]1[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]1)[CH:6]=[CH:5]2

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 587653254-(6-Fluoroquinolin-2-yl)piperazine-1-carbaldehyde

Product 1

HCID 442203176-Fluoro-2-piperazin-1-yl-quinoline

Procedure

The title compound may be prepared by treatment of 4-(6-fluoroquinolin-2-yl)piperazine-1-carbaldehyde of Step E with 4M sulfuric acid.

Sources & evidence

ORD record
ord-b73243fa221b44038d723d9831b965fb
Source dataset
uspto-grants-2006_12
Patent number
US07153849B2

Reaction notes

Loading…