2-Aminopyridine → 2-Amino-1-(3-ethoxy-2,3-dioxopropyl)pyridin-1-ium bromide

Participants

Reaction Steps

Ethyl bromopyruvate (51.9 g, 266 mmol) was added dropwise to a solution of 2-aminopyridine (25 g, 266 mmol) in ethylene glycol dimethyl ether (270 mL), and the reaction then stirred at room temperature for 1 hour. The resulting precipitate was filtered off, the solid washed with ether and dried to afford the title compound as a pale yellow solid, 71.9 g.

Provenance & Evidence