HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 5-[6-(4-Methoxy-benzylamino)-pyridin-2-yl]-pentanoic acid butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 5-[6-(4-Methoxy-benzylamino)-pyridin-2-yl]-pent-4-ynoic acid butyl ester | HCID 69666033 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Adams' catalyst | HCID 345198 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-[6-(4-Methoxy-benzylamino)-pyridin-2-yl]-pentanoic acid butyl ester | HCID 69666541 | 94.5% |
Reaction Steps
A mixture of 6-5 (6.54 g, 17.8 mmol), Et3N (1.85 mL, 13.3 mmol), and PtO2 (0.405 g, 1.78) in EtOH (150 mL) was stirred under a balloon of hydrogen for 6 h. Filtration through celite and evaporative removal of the solvent afforded 6.23 g of 6-6 as a colorless oil. The crude product was used directly in the next step without purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07153862B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-26240f8d8a25487a9dcb69b83d72ba7d |
| Source note | uspto-grants-2006_12 |