HCID 69666758, compound → HCID 58765553, compound

HRID 860070Notes

Reaction equation

HRID 860070 reaction equation
[CH2:1]([O:3][C:4](=[O:31])[CH2:5][C@@H:6]([C:24]1[CH:25]=[N:26][C:27]([CH3:30])=[N:28][CH:29]=1)[CH:7]=[CH:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]1[CH:14]=[CH:15][C:16]2[CH2:22][CH2:21][CH2:20][CH2:19][NH:18][C:17]=2[N:23]=1)[CH3:2].[H][H]>[Pd].C(O)C>[CH2:1]([O:3][C:4](=[O:31])[CH2:5][C@@H:6]([C:24]1[CH:25]=[N:26][C:27]([CH3:30])=[N:28][CH:29]=1)[CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][C:13]1[CH:14]=[CH:15][C:16]2[CH2:22][CH2:21][CH2:20][CH2:19][NH:18][C:17]=2[N:23]=1)[CH3:2]

Participants

5

Reactant 2

HCID 69666758HCID 69666758, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 58765553HCID 58765553, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

A mixture of 8-13 (0.48 g, 1.36 mmol), 10% Pd/C (10 mL), and ethanol (10 mL) was stirred under a balloon of hydrogen for 4 hours. Filtration and concentration gave 8-14 as a yellow oil.

Workup

  1. filtrationFiltration and concentration

Sources & evidence

ORD record
ord-780db99c9f3b4731852b70f832272477
Source dataset
uspto-grants-2006_12
Patent number
US07153862B2

Reaction notes

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