反应详情

温度

150 °C

A solution of the allylic alcohol 22-3 (0.26 g, 0.57 mmol) in (EtO)3CMe (10 mL) was treated with 100 μL of a 1 mL solution of (EtO)3CMe containing 10 μL of propionic acid. The yellow solution was heated at 150° C. for 90 minutes. The solution was cooled to room temperature and poured into 1N HCl/brine. The mixture was extracted with CHCl3, dried, concentrated, and purified on silica gel (90:5:5 CHCl3:EtOAc:MeOH) to give 0.143 g (48%) of 22-4.

1. temperatureThe solution was cooled to room temperature
2. extractionThe mixture was extracted with CHCl3
3. customdried
4. concentrationconcentrated
5. custompurified on silica gel (90:5:5 CHCl3:EtOAc:MeOH)