HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → 7-(2,3-Dihydro-1H-pyrrolo[2,3-b]pyridin-6-yl)-1-(2-methyl-pyrimidin-5-yl)-hept-1-en-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Methylpyrimidine-5-carbaldehyde | HCID 3160970 | — |
| Reactant | [6-(2,3-Dihydro-1H-pyrrolo [2,3-b]pyridin-6-yl)-2-oxo-hexyl]-phosphonic acid dimethyl ester | HCID 20622453 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 7-(2,3-Dihydro-1H-pyrrolo[2,3-b]pyridin-6-yl)-1-(2-methyl-pyrimidin-5-yl)-hept-1-en-3-one | HCID 69666800 | 83% |
Reaction Steps
To a solution of 23-7 (0.49 g, 1.5 mmol) and 2-methyl-pyrimidine-5-carbaldehyde (0.183 g, 1.5 mmol) in 15 mL DMF was added K2CO3 (0.310 g, 2.25 mmol). The mixture was stirred at ambient temperature for 2 hr and concentrated to a paste. The residue was purified by PCTLC (0–10% MeOH/CH2Cl2) which provided 0.400 g (83% yield) of 23-8.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07153862B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-20e915d9ed0b4d939ef3e7dce14c8161 |
| Source note | uspto-grants-2006_12 |