5-iodo-2-isopropyl-1H-imidazole → HCID 178424604, compound

HRID 860141Notes

Reaction equation

HRID 860141 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([C:8]#[C:9][Si](C)(C)C)[CH:5]=[CH:4][N:3]=1.I[C:15]1[NH:19][C:18]([CH:20]([CH3:22])[CH3:21])=[N:17][CH:16]=1>>[CH:20]([C:18]1[NH:17][CH:16]=[C:15]([C:9]#[C:8][C:6]2[CH:5]=[CH:4][N:3]=[C:2]([CH3:1])[CH:7]=2)[N:19]=1)([CH3:22])[CH3:21]

Participants

3

Reactant 2

HCID 121602595-iodo-2-isopropyl-1H-imidazoleHCID 219853962-Methyl-4-((trimethylsilyl)ethynyl)pyridine

Product 1

HCID 178424604HCID 178424604, compound

Procedure

4-(2-Isopropyl-1H-imidazol-4-ylethynyl)-2-methyl-pyridine (II-2) [MS: m/e=226.4 (M+H+)] was prepared in analogy to the method as described in example II-1, method A2, step 3 from 2-methyl-4-trimethylsilanylethynyl-pyridine and 5-iodo-2-isopropyl-1H-imidazole.

Sources & evidence

ORD record
ord-edd3d8da91f044b08d316eeb4033bd8f
Source dataset
uspto-grants-2006_12
Patent number
US07153874B2

Reaction notes

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