2-Methoxyethanol → HCID 9997948, compound

Participants

Reaction Steps

The title compound, MS: m/e=350.4 (M+H+) was prepared by treatment of 100 mg 0.32 mmol) 2-chloro-6-[2-methyl-4-(2-methyl-pyridin-4-ylethynyl)-imidazol-1-yl]-pyrazine (27) with 3 equiv. of 2-methoxyethanol and 3 equiv. of sodium hydride in 5 ml of THF (1 h, 50° C.). The compound, after extraction with methylene chloride/water, was purified by chromatography. Yield: 45 mg (0.13 mmol, 40%).

Provenance & Evidence