HCID 69450603, compound → HCID 69448963, compound

Participants

Reaction Steps

A mixture of the product of Step 1 (1.30 g, 4.9 mmol) and 20% Pd(OH)2 on carbon (600 mg) in MeOH (30 mL) was stirred at RT under an N2 atmosphere for 8 h. The mixture was filtered through a celite pad and the pad washed with MeOH (70 mL). To give after concentrating under reduced pressure, the piperidine (1.25 g, 96%). 1H NMR (CDCl3, 360 MHz) δ7.39 (1H, d, J=1.9 Hz), 6.00 (1H, d, J=1.9 Hz), 4.30–4.17 (2H, m), 3.83 (3H, s), 2.90–2.67 (3H, m), 1.95–1.81 (2H, m), 1.65–1.45 (2H, m), 1.48 (9H, s). MS (ES+) C14H23N3O2 requires: 265, found: 266 (M+H+, 65%).

Provenance & Evidence