HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 860177Generated: October 30, 2026
Diisopropylethylamine → HCID 10110753, compound
https://huagongshe.com/reaction/860177
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Propanedioic acid, 2-phenyl-, 1-(phenylmethyl) ester | HCID 117278 | — |
| Reactant | Benzenecarboximidamide, 4-amino-, hydrochloride (1:1) | HCID 122765 | — |
| Reactant | O-[(Ethoxycarbonyl)cyanomethylenamino]-N,N,N',N'-tetramethyluronium tetrafluoroborate | HCID 2733286 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 10110753 | HCID 10110753 | — |
Reaction Steps
10 g (37 mmol) phenyl malonic acid monobenzyl ester and 7.7 g (37 mmol) 4-amidino aniline hydrochloride were dissolved in 60 ml DMF and cooled to 0° C. 12.2 g (37 mmol) TOTU and 19 ml (111 mmol) DIPEA were added and the mixture stirred at rt overnight. The solvent was removed, the residue taken up in ethyl acetate, and extracted with 10% sodium carbonate solution and brine. After drying over sodium sulfate, the solution was evaporated to dryness and extracted with diethyl ether twice. The remaining solid product was sufficiently pure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07153876B2 |
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| Source dataset | uspto-grants-2006_12 |
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| ORD ID | ord-c428ea3bc47b4a69b4669247d5a38618 |
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| Source note | uspto-grants-2006_12 |
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