反应详情

0.22 g (1.1 mmol) 2-chloro-3,4 dimethoxybenzaldehyde and 0.34 g (1 mmol) N-hydroxy-N′-phenylaminoguanidine tosylate was mixed in 7 ml methanol. The reaction mixture was refluxed for 80 min after which it was cooled down, to room temperature. The solvent was evaporated and 10 ml acetonitile was added and the solution was stirred for 1 h. The precipitate formed was filtered, washed with ether and subseqently dried. The yield of title compound 2 was 0.40 g (77%) as a crystalline solid M.p. 167–169° C.

1. temperatureThe reaction mixture was refluxed for 80 min after which it
2. customThe solvent was evaporated
3. addition10 ml acetonitile was added
4. customThe precipitate formed
5. filtrationwas filtered
6. washwashed with ether
7. customsubseqently dried