HuagongsheHuagongshe Chemistry Print Report · For research reference only
Homoserine lactone hydrobromide → 3-(N'-(3,5-Difluorophenylacetyl)-L-alaninyl)-amino-gamma-butyrolactone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Homoserine lactone hydrobromide | HCID 73508 | — |
| Reactant | (2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid | HCID 12135350 | — |
| Product | 3-(N'-(3,5-Difluorophenylacetyl)-L-alaninyl)-amino-gamma-butyrolactone | HCID 86584967 | — |
Reaction Steps
Following General Procedure A above using N-(3,5-difluorophenylacetyl)-L-alanine (Example B) and α-amino-γ-butyrolactone hydrobromide (Aldrich), the title compound was prepared as a solid having a melting point of 174–177° C. The reaction was monitored by tlc on silica gel (Rf=0.52 in 10% methanol/dichloromethane) and purification was by silica gel chromatography.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07153847B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-84a1efca2f954a49957f011deb75940c |
| Source note | uspto-grants-2006_12 |