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N-(3,4-dichlorophenyl)alanine → 3-(N'-(3,4-Dichlorophenyl)-D,L-alaninyl)amino-epsilon-caprolactam
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-(3,4-dichlorophenyl)alanine | HCID 5491659 | — |
| 反応物 | (S)-4-Aminoazepan-2-one | HCID 18603542 | — |
| 生成物 | 3-(N'-(3,4-Dichlorophenyl)-D,L-alaninyl)amino-epsilon-caprolactam | HCID 69268404 | — |
反応手順
Following General Procedure A above using N-(3,4-dichlorophenyl)-D,L-alanine (Example Q) and 3-(S)-amino-ε-caprolactam (Sigma), the title compound was prepared as a solid having a melting point of 199° C. The reaction was monitored by tlc on silica gel (Rf=0.4 in 50% ethyl acetate/hexanes) and purification was by preparative thin layer chromatography using 50% ethyl acetate/hexanes as the eluant.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07153847B2 |
| 出典データセット | uspto-grants-2006_12 |
| ORD ID | ord-122adebee43b421cac611102a9d67c83 |
| 出典メモ | uspto-grants-2006_12 |