(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid → HCID 10193994, compound

HRID 860225Notes

Reaction equation

HRID 860225 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([NH:12][C@H:13]([C:15]([OH:17])=O)[CH3:14])=[O:11])[CH:5]=[C:6]([F:8])[CH:7]=1.N[CH:19]1C2C(=CC=CC=2)[CH:22]([C:29]2[CH:34]=[CH:33][CH:32]=[CH:31][N:30]=2)[NH:21][C:20]1=[O:35]>>[F:8][C:6]1[CH:5]=[C:4]([CH2:9][C:10]([NH:12][C@H:13]([C:15]([NH:30][CH:31]2[CH2:32][CH2:33][CH2:34][CH2:29][CH2:22][NH:21][C:20](=[O:35])[CH2:19]2)=[O:17])[CH3:14])=[O:11])[CH:3]=[C:2]([F:1])[CH:7]=1

Participants

3

Reactant 2

HCID 12135350(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acidHCID 22312258HCID 22312258, compound

Product 1

HCID 10193994HCID 10193994, compound

Procedure

Following General Procedure B above using N-(3,5-difluorophenylacetyl)-L-alanine (Example B) and 3-amino-8-octanelactam (i.e., 2-oxo-1-azacyclononane prepared as described in General Procedure 5-C), the title compound was prepared as a solid having a melting point of >220° C.

Sources & evidence

ORD record
ord-d933e54a8caa4da38863bbe5a675c65d
Source dataset
uspto-grants-2006_12
Patent number
US07153847B2

Reaction notes

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