HCID 11601953, compound → HCID 10280077, compound

HRID 860245Notes

Reaction equation

HRID 860245 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([NH:12][C@H:13]([C:15]([OH:17])=O)[CH3:14])=[O:11])[CH:5]=[C:6]([F:8])[CH:7]=1.[NH2:18][N:19]1[C:25](=[O:26])[CH:24]([CH:27]2[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]2)[C:23]2[CH:33]=[CH:34][CH:35]=[CH:36][C:22]=2[C:21]2[CH:37]=[CH:38][CH:39]=[CH:40][C:20]1=2>CO.C(Cl)(Cl)Cl>[F:8][C:6]1[CH:5]=[C:4]([CH2:9][C:10]([NH:12][C@H:13]([C:15]([NH:18][N:19]2[C:25](=[O:26])[CH:24]([CH:27]3[CH2:28][CH2:29][CH2:30][CH2:31][CH2:32]3)[C:23]3[CH:33]=[CH:34][CH:35]=[CH:36][C:22]=3[C:21]3[CH:37]=[CH:38][CH:39]=[CH:40][C:20]2=3)=[O:17])[CH3:14])=[O:11])[CH:3]=[C:2]([F:1])[CH:7]=1

Participants

4

Reactant 2

HCID 11601953HCID 11601953, compoundHCID 12135350(2S)-2-[[2-(3,5-difluorophenyl)acetyl]amino]propanoic acid

Product 1

HCID 10280077HCID 10280077, compound

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

Following General Procedure D and using N-(3,5-difluorophenylacetyl)-L-alanine (Ex. B) and 5-amino-7-cyclohexyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one (Example 7-N), the title compound was prepared. The reaction was monitored by tlc (Rf=0.35, 5% MeOH/CHCl3) and product was purified by chromatography (silica, 5% MeOH/CHCl3).

Workup

  1. customwas purified by chromatography (silica, 5% MeOH/CHCl3)

Sources & evidence

ORD record
ord-4e7727535e9246beabf5a0235fe2af0f
Source dataset
uspto-grants-2006_12
Patent number
US07153847B2

Reaction notes

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