Benzeneacetic acid, 3,5-difluoro-α-hydroxy-, (αS)- → HCID 131723825, compound

HRID 860248Notes

Reaction equation

HRID 860248 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH:10]=[C:11]([F:13])[CH:12]=1)[C@H:5]([OH:9])[C:6]([OH:8])=O.Cl.[NH2:15][C@H:16]([C:18]([NH:20][N:21]1[C:27](=[O:28])[CH:26]([CH2:29][CH2:30][CH2:31][CH2:32][C:33]2[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=2)[C:25]2[CH:39]=[CH:40][CH:41]=[CH:42][C:24]=2[C:23]2[CH:43]=[CH:44][CH:45]=[CH:46][C:22]1=2)=[O:19])[CH3:17]>>[F:13][C:11]1[CH:10]=[C:4]([CH:3]=[C:2]([F:1])[CH:12]=1)[C@H:5]([OH:9])[C:6]([NH:15][C@H:16]([C:18]([NH:20][N:21]1[C:27](=[O:28])[CH:26]([CH2:29][CH2:30][CH2:31][CH2:32][C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=2)[C:25]2[CH:39]=[CH:40][CH:41]=[CH:42][C:24]=2[C:23]2[CH:43]=[CH:44][CH:45]=[CH:46][C:22]1=2)=[O:19])[CH3:17])=[O:8]

Participants

3

Reactant 2

HCID 6951479Benzeneacetic acid, 3,5-difluoro-α-hydroxy-, (αS)-HCID 69033209HCID 69033209, compound

Product 1

HCID 131723825HCID 131723825, compound

Procedure

Following General Procedure D and using (S)-3,5-difluoromandelic acid (Example L) and 5-(L-alaninyl)-amino-7-phenbutyl-5,7-dihydro-6H-dibenz[b,d]azepin-6-one hydrochloride (Example 7-S), the title compound was prepared. The product was purified by chromatography (silica, 1–2% MeOH/CHCl3).

Workup

  1. customThe product was purified by chromatography (silica, 1–2% MeOH/CHCl3)

Sources & evidence

ORD record
ord-22448a983f174d989bfa4ad9f3766f06
Source dataset
uspto-grants-2006_12
Patent number
US07153847B2

Reaction notes

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