HuagongsheHuagongshe Chemistry Print Report · For research reference only
(3,5-Difluorophenyl)glyoxylic acid → 3-[N'-(3,5-Difluorophenyl-alpha-oxoacetyl)-L-alaninyl]amino-2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (3,5-Difluorophenyl)glyoxylic acid | HCID 22312040 | — |
| Reactant | 3-(L-alaninyl)amino-2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepin-2-one | HCID 23552762 | — |
| Product | 3-[N'-(3,5-Difluorophenyl-alpha-oxoacetyl)-L-alaninyl]amino-2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepin-2-one | HCID 22984133 | — |
Reaction Steps
Following General Procedure D above using 3,5-difluoro-α-oxoacetic acid (Example O) and 3-(L-alaninyl)amino-2,3-dihydro-1-methyl-5-phenyl-1H-1,4-benzodiazepin-2-one (Example 8-B), the title compound was prepared as a solid (mp.=128–129° C.). The product was purified by LC 2000 chromatography, eluting with hexanes/ethyl acetate (30:70).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07153847B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-f5c8b50c110142ba91bbc05b8df93bce |
| Source note | uspto-grants-2006_12 |