3,4-Dichlorophenylacetic acid → 2-[(3,4Dichlorophenyl)acetamido]butyric acid isobutyl ester

HRID 860352Notes

Reaction equation

HRID 860352 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH2:9][C:10]([OH:12])=O)[CH:5]=[CH:6][C:7]=1[Cl:8].[NH2:13][CH:14]([CH2:22][CH3:23])[C:15]([O:17][CH2:18][CH:19]([CH3:21])[CH3:20])=[O:16]>>[CH2:18]([O:17][C:15](=[O:16])[CH:14]([NH:13][C:10](=[O:12])[CH2:9][C:4]1[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=1)[CH2:22][CH3:23])[CH:19]([CH3:20])[CH3:21]

Participants

3

Reactant 2

HCID 798743,4-Dichlorophenylacetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 543898612-[(3,4Dichlorophenyl)acetamido]butyric acid isobutyl ester

Procedure

Following General Procedure BI above and using 3,4-dichlorophenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure BJ above) the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Sources & evidence

ORD record
ord-939b7b8e63954ae6b8fcbeab12fa8b88
Source dataset
uspto-grants-2006_12
Patent number
US07153847B2

Reaction notes

Loading…