(4-Chlorophenyl)acetic acid → 2-[(4chlorophenyI)acetamido]butyric acid iso-butyl ester

HRID 860354Notes

Reaction equation

HRID 860354 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=O)=[CH:4][CH:3]=1.[NH2:12][CH:13]([CH2:21][CH3:22])[C:14]([O:16][CH2:17][CH:18]([CH3:20])[CH3:19])=[O:15]>>[CH2:17]([O:16][C:14](=[O:15])[CH:13]([NH:12][C:9](=[O:11])[CH2:8][C:5]1[CH:4]=[CH:3][C:2]([Cl:1])=[CH:7][CH:6]=1)[CH2:21][CH3:22])[CH:18]([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 15880(4-Chlorophenyl)acetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 540487372-[(4chlorophenyI)acetamido]butyric acid iso-butyl ester

Procedure

Following General Procedure BI above and using 4-chlorophenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-7e80aee0d14f4ae9b42560dfd6e52204
Source dataset
uspto-grants-2006_12
Patent number
US07153847B2

Reaction notes

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