(2-Hydroxyphenyl)acetic acid → 2-[(2-Hydroxyphenyl)acetamido]butyric acid isobutyl ester

HRID 860356Notes

Reaction equation

HRID 860356 reaction equation
[OH:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[CH2:8][C:9]([OH:11])=O.[NH2:12][CH:13]([CH2:21][CH3:22])[C:14]([O:16][CH2:17][CH:18]([CH3:20])[CH3:19])=[O:15]>>[CH2:17]([O:16][C:14](=[O:15])[CH:13]([NH:12][C:9](=[O:11])[CH2:8][C:3]1[CH:4]=[CH:5][CH:6]=[CH:7][C:2]=1[OH:1])[CH2:21][CH3:22])[CH:18]([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 11970(2-Hydroxyphenyl)acetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 537176952-[(2-Hydroxyphenyl)acetamido]butyric acid isobutyl ester

Procedure

Following General Procedure BI above and using 2-hydroxyphenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-02cf1c646da74f07aef33321dfeebc36
Source dataset
uspto-grants-2006_12
Patent number
US07153847B2

Reaction notes

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