3-Fluorophenylacetic acid → 2-[(3-Fluorophenyl)acetamido]butyric acid isobutyl ester

HRID 860360Notes

Reaction equation

HRID 860360 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=O)[CH:5]=[CH:6][CH:7]=1.[NH2:12][CH:13]([CH2:21][CH3:22])[C:14]([O:16][CH2:17][CH:18]([CH3:20])[CH3:19])=[O:15]>>[CH2:17]([O:16][C:14](=[O:15])[CH:13]([NH:12][C:9](=[O:11])[CH2:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=1)[CH2:21][CH3:22])[CH:18]([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 676173-Fluorophenylacetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 540199252-[(3-Fluorophenyl)acetamido]butyric acid isobutyl ester

Procedure

Following General Procedure BI above and using 3-fluorophenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-6c2864c1dff445c39dfd8d8cbb98a552
Source dataset
uspto-grants-2006_12
Patent number
US07153847B2

Reaction notes

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