2-(4-Fluorophenyl)acetic acid → 2-[(4-Fluorophenyl)acetamido]butyric acid isobutyl ester

HRID 860363Notes

Reaction equation

HRID 860363 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([OH:11])=O)=[CH:4][CH:3]=1.[NH2:12][CH:13]([CH2:21][CH3:22])[C:14]([O:16][CH2:17][CH:18]([CH3:20])[CH3:19])=[O:15]>>[CH2:17]([O:16][C:14](=[O:15])[CH:13]([NH:12][C:9](=[O:11])[CH2:8][C:5]1[CH:4]=[CH:3][C:2]([F:1])=[CH:7][CH:6]=1)[CH2:21][CH3:22])[CH:18]([CH3:19])[CH3:20]

Participants

3

Reactant 2

HCID 98372-(4-Fluorophenyl)acetic acidHCID 13743360Isobutyl 2-aminobutyrate

Product 1

HCID 541443992-[(4-Fluorophenyl)acetamido]butyric acid isobutyl ester

Procedure

Following General Procedure BI above and using 4-fluorophenylacetic acid (Aldrich) and iso-butyl 2-aminobutyrate (prepared following General Procedure BJ above), the title compound was prepared. The reaction was monitored by tlc on silica gel and purification was by filtration as described in the general procedure.

Workup

  1. customThe reaction was monitored by tlc on silica gel and purification
  2. filtrationwas by filtration

Sources & evidence

ORD record
ord-122237a15a7a48558822afafb383901a
Source dataset
uspto-grants-2006_12
Patent number
US07153847B2

Reaction notes

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