4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine → N-[6-chloro-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]-2-phenylethanesulfonamide

Participants

Role	Name	HCID	Charge
Reactant	4,6-Dichloro-5-(2-methoxyphenoxy)-2,2'-bipyrimidine	HCID 10545706	—
Reactant	2-Phenyl-ethanesulfonic acid [6-(2-hydroxy-ethoxy)-5-p-tolyl-pyrimidin-4-yl]-amide	HCID 23548269	—
Product	N-[6-chloro-5-(2-methoxyphenoxy)-2-pyrimidin-2-ylpyrimidin-4-yl]-2-phenylethanesulfonamide	HCID 71500856	—

Reaction Steps

2-Phenylethanesulfonic acid [6-chloro-5-(2-methoxy-phenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]-amide was prepared in analogy to Referential Example 7 from 4,6-dichloro-5-(2-methoxyphenoxy)-2-(2-pyrimidinyl)-pyrimidine (prepared as disclosed in [6]) and 2-phenylethane sulfonamide potassium salt (Referential Example 1). LC-MS: tR=4.85 min, [M+1]+=498.38, [M−1]−=496.19.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07091201B2
Source dataset	uspto-grants-2006_08
ORD ID	ord-9112175213df4b35b132a5d7ccb85bbe
Source note	uspto-grants-2006_08