Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | Ethyl 7-acetyl-7-(4-cyanobenzoyl)-8-oxononanoate | HCID 57444529 | — |
| Solvent | Trifluoroacetic acid | HCID 6422 | — |
| Product | HCID 57444530 | HCID 57444530 | 72.5% |
Reaction Steps
Ethyl 7-acetyl-7-(4-cyanobenzoyl)-8-oxononanoate (3.5 g) was dissolved in trifluoroacetic acid (12.6 ml) and the mixture was stirred at 20° C. for 15 minutes. The mixture was partitoned between ethyl acetate and water. The organic layer was separated, washed with water, aqueous sodium bicarbonate and brine, dried over MgSO4 (magnesium sulfate), and evaporated to give ethyl 7-(4-cyanobenzoyl)-8-oxononanoate (2.25 g) as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07153854B2 |
|---|
| Source dataset | uspto-grants-2006_12 |
|---|
| ORD ID | ord-e00be75486dc4cbcb2c46c3115462fa4 |
|---|
| Source note | uspto-grants-2006_12 |
|---|
