反应详情

A suspension of methyl 4-({[(benzyloxy)carbonyl]amino}-sulfonyl)benzoate (3.38 g) and 85% pottasium hydroxide (1.28 g) in methanol (40 mL) was stirred for 35 minutes. Methanol was evaporated off, and to the mixture was added 1N hydrochloric acid (20 mL). A white crystal was formed, which was collected by filtration and washed with water and diisopropyl ether, and dried under vacuum. 4-({[(Benzyloxy)carbonyl]amino}sulfonyl)benzoic acid was obtained as a white crystal (2.92 g).

1. customMethanol was evaporated off
2. additionto the mixture was added 1N hydrochloric acid (20 mL)
3. customA white crystal was formed
4. filtrationwhich was collected by filtration
5. washwashed with water and diisopropyl ether
6. customdried under vacuum