2-Methoxybiphenyl → HCID 15085005, compound

Participants

Reaction Steps

To a solution of 2-phenylanisole (18.27 g, 0.099 mol) in CH2Cl2 (350 mL) was added pyridinium tribromide (34.88 g, 0.109 mol). The resulting mixture was allowed to stir at RT overnight. The mixture was diluted with CH2Cl2 and H2O and the layers were separated, the aqueous layer was extracted with CH2Cl2 (3×). The combined organic layers were washed with H2O, brine and dried with MgSO4. The mixture was filtered and the solvents evaporated to give 2-phenyl-4-bromoanisole as a reddish oil (26.05 g, 100%). 1H NMR (300 MHz, CDCl3): δ 3.75 (s, 3H), 6.82 (d, J=8.7 Hz, 1H), 7.28–7.43 (m, 5H), 7.45–7.49 (m, 2H).

Provenance & Evidence