4-(Trifluoromethyl)thiobenzamide → HCID 69056994, compound

HRID 860611Notes

Reaction equation

HRID 860611 reaction equation
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:11]=[CH:10][C:6]([C:7]([NH2:9])=[S:8])=[CH:5][CH:4]=1.[CH3:14][O:15][C:16](=[O:26])[C:17]([CH3:25])([CH3:24])[C:18](=O)[CH:19](Br)[CH2:20][CH3:21]>C(O)C>[CH3:14][O:15][C:16](=[O:26])[C:17]([CH3:25])([C:18]1[N:9]=[C:7]([C:6]2[CH:10]=[CH:11][C:3]([C:2]([F:1])([F:12])[F:13])=[CH:4][CH:5]=2)[S:8][C:19]=1[CH2:20][CH3:21])[CH3:24]

Participants

4

Reactant 2

HCID 27348234-(Trifluoromethyl)thiobenzamideHCID 85860554HCID 85860554, compound

Product 1

HCID 69056994HCID 69056994, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 4-Trifluoromethyl-thiobenzamide (12.3 g, 60 mmol) and the crude product from step A (16.6 g, 66 mmol) in ethanol (600 mL) is heated to reflux for 3 days. Solvent is evaporated and the residue is purified by chromatography on silica gel yielding the title compounds (14.5 g).

Workup

  1. temperatureto reflux for 3 days
  2. customSolvent is evaporated
  3. customthe residue is purified by chromatography on silica gel yielding the title compounds (14.5 g)

Sources & evidence

ORD record
ord-ae5fd30f7ebe43dc80a91d316bffe7a1
Source dataset
uspto-grants-2006_12
Patent number
US07153878B2

Reaction notes

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