HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(4-Hydroxymethyl-2-methyl-phenyl)-acrylic Acid Methyl Ester → 3-(4-Hydroxymethyl-2-methyl-phenyl)-propionic Acid Methyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(4-Hydroxymethyl-2-methyl-phenyl)-acrylic Acid Methyl Ester | HCID 68838057 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 3-(4-Hydroxymethyl-2-methyl-phenyl)-propionic Acid Methyl Ester | HCID 57431976 | — |
Reaction Steps
A mixture of 3-(4-Hydroxymethyl-2-methyl-phenyl)-acrylic acid methyl ester (4.7 g, 22.8 mmol), Raney nickel (0.668 g) and tetrahydrofuran (618 mL) is shaken under 60 psig. Hydrogen 24 hr. The catalyst is filtered off, and the mixture is concentrated to afford the product as a pale yellow oil, 4.3 g, 91%. The structure is confirmed by 1H NMR spectroscopy.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07153878B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-24ef3610fdca4e7089b3c73f394ef59a |
| Source note | uspto-grants-2006_12 |