HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(2-Methyl-4-nitro-phenyl)-acrylic Acid Methyl Ester → Methyl 3-(4-amino-2-methylphenyl)propanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(2-Methyl-4-nitro-phenyl)-acrylic Acid Methyl Ester | HCID 68839650 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 3-(4-amino-2-methylphenyl)propanoate | HCID 54187007 | 77.2% |
Reaction Steps
A mixture of 3-(2-Methyl-4-nitro-phenyl)-acrylic acid methyl ester (1.47 g, 6.64 mmol) and 5% Pd/C (0.29 g) in MeOH (100 mL) is exposed to a hydrogen atmosphere (60 psi) for 12 h. The mixture is filtered through Celite and purified by flash chromatography to yield the title compound (0.99 g, 77%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07153878B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-83720905f0f5408f91f7025b1c53d626 |
| Source note | uspto-grants-2006_12 |