HuagongsheHuagongshe Chemistry Print Report · For research reference only
Water → 3-(4-Azidomethyl-2-methyl-phenyl)-propionic Acid Methyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Sodium Azide | HCID 33557 | — |
| Reactant | 3-(4-Chloromethyl-2-methyl-phenyl)-propionic Acid Methyl Ester | HCID 57431981 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-(4-Azidomethyl-2-methyl-phenyl)-propionic Acid Methyl Ester | HCID 57431982 | 91% |
Reaction Steps
To a solution of 3-(4-Chloromethyl-2-methyl-phenyl)-propionic acid methyl ester (0.52 g, 2.31 mmol) in DMF (7 mL) is added sodium azide (0.25 g, 3.84 mmol). The mixture is stirred overnight. Water is added, and the mixture is extracted with EtOAc. The organics are dried with Na2SO4 and concentrated to yield the title compound (0.49 g, 91%). The material is used without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07153878B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-5304e71abee043bd9ca98bd9be0a0fa4 |
| Source note | uspto-grants-2006_12 |