Sulfuric Acid → HCID 58765776, compound

Participants

Reaction Conditions

Reaction Steps

3-(4-Bromo-benzoylamino)-4-oxo-pentanoic acid methyl ester is dissolved in acetic anhydride (75 mL) and concentrated sulfuric acid is added in 500 uL portions five times over a four hour period. The reaction is monitored by HPLC. The reaction is then heated to 40° C. until the starting material is consumed. The reaction is then concentrated to dryness and purified by column chromatography. This procedure yielded (11.6 g, 37.4 mmol) 48.3% of the desired oxazole.

Provenance & Evidence