HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 860673Generated: October 30, 2026
Sodium Carbonate → HCID 58765658, compound
https://huagongshe.com/reaction/860673
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 2-Bromopyrimidine | HCID 78345 | — |
| Reactant | HCID 58765674 | HCID 58765674 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 58765658 | HCID 58765658 | — |
Reaction Steps
A solution of 3-[4-(2-{4-isopropyl-2-[4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-phenyl]-oxazol-5-yl}-propoxy)-2-methyl-phenyl]-propionic acid methyl ester (91 mg, 0.166 mmol) in toluene (4.0 mL) is bubbled with nitrogen gas for 10 minutes. To this, Pd(dppf)Cl2 (10 mg), Na2CO3 (1.0 mL, 2.0 M), 2-bromopyrimidine (53 mg, 0.333 mmol) are added. The resulting suspension is stirred and heated at 90° C. for 48 hours. It is then concentrated, purified on silica gel chromatography column with 20–40% EtOAc/Hexanes to yield the pyrimidine intermediate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07153878B2 |
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| Source dataset | uspto-grants-2006_12 |
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| ORD ID | ord-25a4b4b1c44a4205b836080fec63cb32 |
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| Source note | uspto-grants-2006_12 |
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