Methanol → HCID 58765742, compound

Participants

Reaction Steps

(4-{2-[4-Isopropyl-2-(4-trifluoromethyl-phenyl)-oxazol-5-yl]-propoxy}-2-methyl-phenyl)-acetic acid methyl ester (0.065 g, 0.1367 mmol), lithium hydroxide (0.020 g, 0.8333 mmol) and 3:2:1 tetrahydrofuran:methanol:water (15 mL) is stirred at 60 deg C. 1 hr. The mixture is cooled on ice/water and diluted with 0.2 N aqueous hydrochloric acid. The product is extracted to ethyl acetate (2×50 mL), the extracts combined, dried over anhydrous magnesium sulfate, filtered and concentrated to afford the title compound as a white solid, 55 mg, 87%. MS M++1 462. The structure is confirmed by 1H NMR spectroscopy.

Provenance & Evidence