HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethanol → HCID 69589287, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethanol | HCID 702 | — |
| Reactant | Methyl 4-bromo-2-methyl-3-oxopentanoate | HCID 24978315 | — |
| Reactant | HCID 86598135 | HCID 86598135 | — |
| Product | HCID 69589287 | HCID 69589287 | — |
Reaction Steps
A mixture of 6-(2-Fluoro-phenyl)-thionicotinamide (3.0 g, 12 mmol) and 4-bromo-3-oxo-2-methyl-pentanoic acid methyl ester (3.2 g, 14.4 mmol) in ethanol (100 mL) is heated to reflux for 24 h, and concentrated. The residue is purified by column chromatography on silica gel yielding 2.6 g of the product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07153878B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-7fae0e6149cb4b9f8e1dd564b4052788 |
| Source note | uspto-grants-2006_12 |