Aluminium lithium hydride → HCID 69589367, compound

Participants

Reaction Steps

To a solution of 2-{2-[6-(2-Fluoro-phenyl)-pyridin-3-yl]-5-methyl-thiazol-4-yl}-propionic acid ethyl ester (2.6 g, 7.03 mmol) in THF (15 mL) is added LiAlH4 (1.0 M in THF, 7.1 mL, 7.1 mmol) at 0–5° C., and then stirred for 2 h. The reaction is then quenched by water and 5 N NaOH, diluted with THF and filtered through a pad of celite. The filtrate is concentrated and purified by column yielding 1.8 g of the product.

Provenance & Evidence