Ammonia → HCID 69377277, compound

Participants

Reaction Steps

2,5-Dichloro4-(2-cyanoanilino)pyrimidine (265 mg, 1.00 mmol) was dissolved in n-butanol (1 ml) and sulphanilamide (207 mg, 1.20 mmol) was added. The resulting suspension was heated at reflux for 2 hours and allowed to cool to ambient temperature. The reaction mixture was then basified using methanolic ammonia and evaporated onto silica. The residue was purified by column chromatography eluting with 0–15% 2.0M methanolic ammonia solution in dichloromethane to afford a solid product (42.6 mg). NMR (303.1K): 7.09 (2H, s), 7.41–7.59 (5H, m), 7.65 (1H, d), 7.74–7.86 (1H, m), 7.94 (1H, d 8.25 (1H, s), 9.46 (1H, s), 9.78 (1H, s); MS (M+H)+: 401, 403.

Provenance & Evidence