1-Butanol → HCID 10278583, compound

Participants

Reaction Steps

A solution of 5-bromo-2,4-dichloropyrimidine (228 mg, 1.0 mmol), 4-sulphanilamide (180 mg, 1.05 mmol) and N,N-diisopropylethylamine (174 μl 1.0 mmol) in n-butanol (30 ml) was heated at 100° C. for 16 hours. A gum formed out of solution. Diethyl ether (20 ml) was added, causing the gum to solidify, and further precipitation to occur. The solid was collected by filtration and triturated with hot methanol, giving the title product (55 mg) as a white solid. NMR: (s, 2H), 7.30 (s, 2H), 7.64 (d, 2H), 7.80 (m, 4H), 7.88 (d, 2H), 8.36 (s, 1H), 8.93 (s, 1H), 9.88 (s, 1H).

Provenance & Evidence