反应详情

The 14-hydroxycodeinone (39.45 g of the damp solid) was dissolved in water (81.13 ml) and 80% acetic acid (16.17 ml). 10 wt % palladium on carbon catalyst (0.33 g wet weight, 0.16 g dry weight) was added and hydrogen was passed through the mixture for about 6 hours at about 12 psi. The mixture was filtered to remove the catalyst. An ammonium hydroxide solution was added to the mixture up to pH 9. The solid precipitate was washed with water and with ethanol, and was dried. The product was oxycodone (18.8 g, 79% yield).

1. filtrationThe mixture was filtered
2. customto remove the catalyst
3. additionAn ammonium hydroxide solution was added to the mixture up to pH 9
4. washThe solid precipitate was washed with water and with ethanol
5. customwas dried