3-Mercaptopropionic Acid → HCID 69021738, compound

HRID 860794Notes

Reaction equation

[SH:1][CH2:2][CH2:3][C:4]([OH:6])=[O:5].[NH2:7][C:8]1[CH:13]=[CH:12][C:11]([CH:14]([C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=2)[C:15]2[N:19]([CH3:20])[CH:18]=[N:17][CH:16]=2)=[CH:10][C:9]=1[CH:28]([C:30]1[CH:35]=[CH:34][CH:33]=[C:32]([Cl:36])[CH:31]=1)O>O1CCOCC1>[NH2:7][C:8]1[CH:13]=[CH:12][C:11]([CH:14]([C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=2)[C:15]2[N:19]([CH3:20])[CH:18]=[N:17][CH:16]=2)=[CH:10][C:9]=1[CH:28]([C:30]1[CH:35]=[CH:34][CH:33]=[C:32]([Cl:36])[CH:31]=1)[S:1][CH2:2][CH2:3][C:4]([OH:6])=[O:5]

Participants

Conditions

Temperature: 80 °C

Procedure

3-mercapto-propanoic acid (0.00433 mol) was added slowly to a mixture of intermediate (17) (0.00456 mol) in dioxane (20 ml) and D (20 ml). The mixture was stirred at 80° C. for 5 hours. The solvent was evaporated till dryness. The product was used without further purification, yielding 3-[[[2-amino-5-[(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]phenyl](3-chlorophenyl)methyl]thio]-propanoic acid (intermediate 22).

Workup

customThe solvent was evaporated till dryness
customThe product was used without further purification

Sources & evidence

ORD record: ord-91a5f9d538ce468384fd6bb30939a976
Source dataset: uspto-grants-2006_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07153958B2

Reaction notes

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