反应详情

温度

190 °C

Dodecanethiol (122 g), venlafaxine (111 g), and a methanolic solution of sodium methanolate (30%, 90 g) and PEG 400 are heated to 190° C. The methanol is distilled off and the solution is stirred for 2 hours at 190° C. Then the temperature is lowered, 2-propanol (450 g) is added and the pH is adjusted to 9.5 with aqueous HCl. The precipitate is collected by suction filtration, and the cake is washed with 2-propanol, toluene, 2-propanol and water. The wet O-desmethylvenlafaxine is dried in vacuo.

1. distillationThe methanol is distilled off
2. addition2-propanol (450 g) is added
3. filtrationThe precipitate is collected by suction filtration
4. washthe cake is washed with 2-propanol, toluene, 2-propanol and water
5. dry with materialThe wet O-desmethylvenlafaxine is dried in vacuo