反应详情

温度

160 °C

Venlafaxine (5.6 g) and benzenethiol sodium salt (6.9 g) are charged to PEG 400 (25 g). The reaction mixture is heated to 160° C. for 5 hours. Then the temperature is lowered and water is added (60 g). The pH is adjusted to 3.5 with H3PO4. The organic by-products are removed by extraction with heptanes (25 g). The pH of the aqueous layer is then adjusted to 9.5 with aqueous ammonia. The precipitate is collected by suction filtration, re-slurried in water (100 g), isolated by suction filtration and dried in vacuo.

1. customThe organic by-products are removed by extraction with heptanes (25 g)
2. filtrationThe precipitate is collected by suction filtration, re-slurried in water (100 g)
3. customisolated by suction filtration
4. customdried in vacuo