HCID 69384357, compound → HCID 69385550, compound

Participants

Reaction Steps

A mixture of methyl-N-[3,5-dichloro-4-(5-isopropyl-4-methoxy-3-nitro-phenoxy)benzoyl]glycine (380 mg, 0.81 mmol) and PtO2 (40 mg) in ethyl acetate (10 mL) was stirred at room temperature under hydrogen (atmospheric pressure) for 24 h. Pt catalyst was removed by filtration through celite and the filtrate was concentrated, which was purified on column (silica gel, n-heptane/ethyl acetate, gradient elution from 98:2 to 60:40) to give 320 mg (89%) of methyl-N-[3,5-dichloro-4-(3-amino-5-isopropyl-4-methoxyphenoxy)benzoyl]glycine.

Provenance & Evidence