HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium methanesulfinate → 6-(Methylsulfonylmethyl)-8-bromoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium methanesulfinate | HCID 2733271 | — |
| Reactant | 8-Bromo-6-(bromomethyl)quinoline | HCID 15541319 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 6-(Methylsulfonylmethyl)-8-bromoquinoline | HCID 9879373 | — |
Reaction Steps
To a solution of 6-bromomethyl-8-bromoquinoline (1.0 eq.) described in International Patent Publication WO 94/22852 in DMF, was added sodium methanesulfinate (1.4 eq.). After stirring overnight at rt, the mixture was quenched with H2O, stirred for 1 h. The resulting precipitate was isolated by filtration and washed with Et2O to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07153968B2 |
| Source dataset | uspto-grants-2006_12 |
| ORD ID | ord-ab2af15249244257bf748a79b7de789c |
| Source note | uspto-grants-2006_12 |