5-Bromo-2-fluorobenzaldehyde → (5-Bromo-2-fluorophenyl)methanol

Participants

Reaction Steps

To a solution of 5-bromo-2-fluoro-benzaldehyde (1.0 eq.) in MeOH (0.2M) at 0° C. was added portionwise NaBH4 (2.0 eq.). The mixture was stirred at rt for 1 h, poured in HCl (1M) and extracted with EtOAc (2×). The combined organic extracts were washed with brine, dried over Na2SO4, filtered and concentrated to afford the title compound as a white solid.

Provenance & Evidence